Back to Search Start Over

The differential approach to estimation of renal damage in the patients with nephrolithiasis by means of noninva-sive markers

Authors :
Rossolovsky A.N.
Glybochko P.M.
Popkov V.M.
Polozov A.B.
Ponukalin A.N.
Zakharova N.B.
Berezinetz O.L.
Blumberg B.I.
Source :
Саратовский научно-медицинский журнал, Vol 6, Iss 3, Pp 708-715 (2010)
Publication Year :
2010
Publisher :
Saratov State Medical University, 2010.

Abstract

The aim of this study was the estimation of clinical importance markers of renal damage at surgical treatment of nephrolithiasis. We studied results of operations in 110 patients with nephrolithiasis. The study presents new candidates for biochemical markers of acute kidney injury and renal interstitial fibrosis, with potentially high sensitivity and specificity. In this study were measured the concentrations of these biomarkers in urine. We suggested, that increased concentrations molecular mediators of renal damage (L2, IL-18) and interstitial fibrosis (MCP-1, TGFp, IGF1) in the patients with nephrophibrosis and strongetubulointerstitial injury, saved long-time period after operation, has been shown of progression chronic kidney disease

Details

Language :
Russian
ISSN :
19950039 and 20762518
Volume :
6
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Саратовский научно-медицинский журнал
Publication Type :
Academic Journal
Accession number :
edsdoj.6f3cbbfa7ba248dd80dd1e6be38ac4b8
Document Type :
article