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Clinical Characteristics of Patients with Idiopathic Inflammatory Myopathy and Risk Factors for the Development of Interstitial Lung Disease
- Source :
- Zhongguo quanke yixue, Vol 27, Iss 13, Pp 1623-1629 (2024)
- Publication Year :
- 2024
- Publisher :
- Chinese General Practice Publishing House Co., Ltd, 2024.
-
Abstract
- Background Idiopathic inflammatory myopathy (IIM) is a group of connective tissue diseases characterized by muscle inflammation and muscle weakness, lung involvement is an important factor affecting the prognosis of patients. IIM can be classified into different clinical subtypes based on myositis-specific antibodies (MSAs), there are significant differences in clinical manifestations, organ involvement, prognosis and the risk of interstitial lung disease among different clinical subtypes. Objective To explore the characteristics of IIM and its different clinical subtypes, the risk factors for the development of interstitial lung disease. Methods The clinical data of patients hospitalizedin department of rheumatology and immunology of the First Affiliated Hospital of Kunming Medical University and diagnosed with IIM from April 2018 to February 2021 were collected. The included patients were divided into four clinical subtypes based on MSAs, including anti-MDA5-positive dermatomyositis (DM), anti-MDA5-negative DM, immune-mediated necrotizing myositis (IMNM) and anti-synthetase syndrome (ASS) subtypes. The general data, clinical manifestations, laboratory examination results were compared among different clinical subtypes. Multivariate Logistic regression model was established to explore the risk factors for ILD in patients with IIM. Results The 150 patients with IIM were divided into 4 clinical subtypes, including 30 patients with anti-MDA5-positive DM subtype (20.0%), 58 patients with anti-MDA5-negative DM subtype (38.7%), 14 patients with IMNM subtype (9.3%), and 48 patients with ASS subtype (32.0%). There were significant differences in the incidence of muscle weakness, myalgia, ILD, heliotrope rash, shawl sign, Gottron papules or Gottron sign, arthralgia, periungual red spot and dysphagia among the four clinical subtypes (P403.2 μg/L, IgG>14.15 g/L, LDH>359.5 U/L were all risk factors for ILD in IIM (P
Details
- Language :
- Chinese
- ISSN :
- 10079572
- Volume :
- 27
- Issue :
- 13
- Database :
- Directory of Open Access Journals
- Journal :
- Zhongguo quanke yixue
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6f6a0669abbd4e81a58602047a60608c
- Document Type :
- article
- Full Text :
- https://doi.org/10.12114/j.issn.1007-9572.2022.0003