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Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease
- Source :
- Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
- Publication Year :
- 2016
- Publisher :
- Nature Portfolio, 2016.
-
Abstract
- Imaging tools for evaluating progression of Alzheimer’s disease have been lacking. Here the authors develop a blood brain barrier-permeable Aß probe based on a radiolabelled, anti-Aß antibody, and report age-dependent brain uptake visualized in vivo with PET in mouse models of the disease.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 7
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.6ff8814765814c6eabc58af15ab9f554
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/ncomms10759