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Correlation between lipid accumulation product and epigenetic age acceleration in American adults: a cross-sectional analysis using NHANES data

Authors :
Qiqiang Li
Source :
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-8 (2024)
Publication Year :
2024
Publisher :
BMC, 2024.

Abstract

Abstract Background The risks of obesity and epigenetic age acceleration (EAA) have drawn widespread attention. Lipid accumulation product (LAP) is a simple and reliable indicator of obesity; however, the relationship between LAP and EAA remains unclear. Methods Data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2002 were used. The EAA was assessed using a self-administered questionnaire in the database. LAP was calculated based on triglycerides and waist circumference. The association between LAP and EAA was analyzed using logistic regression models, subgroup analysis, and smooth curve fitting. Results A total of 1796 participants were included in the study, of whom 1055 had EAA. After adjusting for relevant covariates, participants with EAA generally had higher LAP levels than those without EAA (258.1 vs. 244.6). Logistic regression analysis showed that individuals in the highest LAP quartile (Q4) were more likely to have EAA than those in the lowest quartile (Q1) (OR = 1.77; 95% CI 1.31–2.39; P

Details

Language :
English
ISSN :
2047783X
Volume :
29
Issue :
1
Database :
Directory of Open Access Journals
Journal :
European Journal of Medical Research
Publication Type :
Academic Journal
Accession number :
edsdoj.705a47f202ec4ee9be1ceb6e369547fe
Document Type :
article
Full Text :
https://doi.org/10.1186/s40001-024-02174-y