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Successful Stem Cell Mobilization and CD34+ Cell Collection in a Poor Mobilizer: A Case Report Utilizing a Combination of Recombinant Growth Colony Stimulating Factor, Recombinant Human Growth Factor, and Plerixafor

Authors :
Maliheh Kazemi Najafabadi
Azadeh Moghaddas
Mozhgan Karimifar
Ali Darakhshandeh
Source :
Journal of Research in Pharmacy Practice, Vol 12, Iss 3, Pp 110-113 (2024)
Publication Year :
2024
Publisher :
Wolters Kluwer Medknow Publications, 2024.

Abstract

Diffuse large B-cell lymphoma is the most prevalent form of non-Hodgkin’s lymphoma that is usually treated with chemoimmunotherapy. If the disease proves refractory or recurrent, the primary treatment approach involves high-dose chemotherapy with bone marrow transplantation. The collection of peripheral blood stem cells before transplantation plays a vital role in the treatment process, necessitating the mobilization of blood stem cells from the bone marrow to the peripheral blood. Despite using standard methods such as granulocyte colony-stimulating factor (G-CSF), chemotherapy, and plerixafor, some patients cannot collect an optimal count of CD34+ cells for transplantation. Managing these patients with poor mobilization poses significant challenges. In this article, we present a case of a poor mobilizer patient who achieved prosperous mobilization by using recombinant human G-CSF, recombinant human growth hormone, and plerixafor.

Details

Language :
English
ISSN :
23199644 and 2279042X
Volume :
12
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Journal of Research in Pharmacy Practice
Publication Type :
Academic Journal
Accession number :
edsdoj.7067555d4a6c432082c1929c3793f7c6
Document Type :
article
Full Text :
https://doi.org/10.4103/jrpp.jrpp_46_23