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Successful Stem Cell Mobilization and CD34+ Cell Collection in a Poor Mobilizer: A Case Report Utilizing a Combination of Recombinant Growth Colony Stimulating Factor, Recombinant Human Growth Factor, and Plerixafor
- Source :
- Journal of Research in Pharmacy Practice, Vol 12, Iss 3, Pp 110-113 (2024)
- Publication Year :
- 2024
- Publisher :
- Wolters Kluwer Medknow Publications, 2024.
-
Abstract
- Diffuse large B-cell lymphoma is the most prevalent form of non-Hodgkin’s lymphoma that is usually treated with chemoimmunotherapy. If the disease proves refractory or recurrent, the primary treatment approach involves high-dose chemotherapy with bone marrow transplantation. The collection of peripheral blood stem cells before transplantation plays a vital role in the treatment process, necessitating the mobilization of blood stem cells from the bone marrow to the peripheral blood. Despite using standard methods such as granulocyte colony-stimulating factor (G-CSF), chemotherapy, and plerixafor, some patients cannot collect an optimal count of CD34+ cells for transplantation. Managing these patients with poor mobilization poses significant challenges. In this article, we present a case of a poor mobilizer patient who achieved prosperous mobilization by using recombinant human G-CSF, recombinant human growth hormone, and plerixafor.
Details
- Language :
- English
- ISSN :
- 23199644 and 2279042X
- Volume :
- 12
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Research in Pharmacy Practice
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.7067555d4a6c432082c1929c3793f7c6
- Document Type :
- article
- Full Text :
- https://doi.org/10.4103/jrpp.jrpp_46_23