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Added value of 18F-FDG PET-CT in staging of Ewing sarcoma in children and young adults

Authors :
Boel Johnsen
Kristine Eldevik Fasmer
Kjetil Boye
Karen Rosendahl
Clement Trovik
Martin Biermann
Stein Magnus Aukland
Source :
European Journal of Hybrid Imaging, Vol 2, Iss 1, Pp 1-11 (2018)
Publication Year :
2018
Publisher :
SpringerOpen, 2018.

Abstract

Abstract Background Ewing sarcoma (ES) is currently staged using Radiography, ultrasound, computed tomography (CT), magnetic resonance imaging (MRI) and skeletal scintigraphy (bone scan). 18F- fluorodeoxyglucose Positron Emission Tomography (18F-FDG PET-CT) is increasingly used for staging and follow-up, but its role is still under evaluation. Objective To evaluate the added information from 18F-FDG PET-CT studies compared to conventional imaging and to estimate radiation doses received from radiological and nuclear medicine imaging during staging of Ewing sarcoma. Material and methods Sixty-one patients under the age of 30 years (mean 16, range 5–26) were diagnosed with Ewing sarcoma in Norway during the period 2005–2012. Nineteen patients met the inclusion criteria for this population-based study: pre therapeutic 18F-FDG PET-CT and a minimum follow-up of 12 months. Imaging reports, medical records and pathology reports were collected and compared for all patients. Biopsy histology, supplementary imaging and long-term follow-up (median 27 months) were taken as composite gold standard. Results 18F-FDG PET-CT detected more lesions than conventional imaging in four patients (21%) but this did not change planned treatment as they all had extensive metastatic disease. The 18F-FDG PET-CT study was false negative in one patient and showed false positive lesions in three patients (16%). The estimated mean (range) effective total radiation dose was from CT: 7 mSv (2–16), skeletal scintigraphy: 3 mSv (0–5) and 18F-FDG PET-CT: 5 mSv (4–6). Conclusion 18F-FDG PET-CT is useful for staging of Ewing sarcoma and increase detection of metastases. False positive lesions are quite common, emphasizing the need for supplementary imaging or biopsy of suspected FDG positive metastases.

Details

Language :
English
ISSN :
25103636
Volume :
2
Issue :
1
Database :
Directory of Open Access Journals
Journal :
European Journal of Hybrid Imaging
Publication Type :
Academic Journal
Accession number :
edsdoj.7078b4644c404cd49a6653a28af3d31d
Document Type :
article
Full Text :
https://doi.org/10.1186/s41824-018-0031-5