Back to Search Start Over

Engineered macrophages: an 'Intelligent Repair' cellular machine for heart injury

Authors :
Zhuo Zhang
Hetian Du
Weijie Gao
Donghui Zhang
Source :
Cell Regeneration, Vol 13, Iss 1, Pp 1-14 (2024)
Publication Year :
2024
Publisher :
SpringerOpen, 2024.

Abstract

Abstract Macrophages are crucial in the heart’s development, function, and injury. As part of the innate immune system, they act as the first line of defense during cardiac injury and repair. After events such as myocardial infarction or myocarditis, numerous macrophages are recruited to the affected areas of the heart to clear dead cells and facilitate tissue repair. This review summarizes the roles of resident and recruited macrophages in developing cardiovascular diseases. We also describe how macrophage phenotypes dynamically change within the cardiovascular disease microenvironment, exhibiting distinct pro-inflammatory and anti-inflammatory functions. Recent studies reveal the values of targeting macrophages in cardiovascular diseases treatment and the novel bioengineering technologies facilitate engineered macrophages as a promising therapeutic strategy. Engineered macrophages have strong natural tropism and infiltration for cardiovascular diseases aiming to reduce inflammatory response, inhibit excessive fibrosis, restore heart function and promote heart regeneration. We also discuss recent studies highlighting therapeutic strategies and new approaches targeting engineered macrophages, which can aid in heart injury recovery.

Details

Language :
English
ISSN :
20459769
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Cell Regeneration
Publication Type :
Academic Journal
Accession number :
edsdoj.70d93fb9b12046e2a28d1a9642b52049
Document Type :
article
Full Text :
https://doi.org/10.1186/s13619-024-00209-7