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Association analyses identify 31 new risk loci for colorectal cancer susceptibility

Authors :
Philip J. Law
Maria Timofeeva
Ceres Fernandez-Rozadilla
Peter Broderick
James Studd
Juan Fernandez-Tajes
Susan Farrington
Victoria Svinti
Claire Palles
Giulia Orlando
Amit Sud
Amy Holroyd
Steven Penegar
Evropi Theodoratou
Peter Vaughan-Shaw
Harry Campbell
Lina Zgaga
Caroline Hayward
Archie Campbell
Sarah Harris
Ian J. Deary
John Starr
Laura Gatcombe
Maria Pinna
Sarah Briggs
Lynn Martin
Emma Jaeger
Archana Sharma-Oates
James East
Simon Leedham
Roland Arnold
Elaine Johnstone
Haitao Wang
David Kerr
Rachel Kerr
Tim Maughan
Richard Kaplan
Nada Al-Tassan
Kimmo Palin
Ulrika A. Hänninen
Tatiana Cajuso
Tomas Tanskanen
Johanna Kondelin
Eevi Kaasinen
Antti-Pekka Sarin
Johan G. Eriksson
Harri Rissanen
Paul Knekt
Eero Pukkala
Pekka Jousilahti
Veikko Salomaa
Samuli Ripatti
Aarno Palotie
Laura Renkonen-Sinisalo
Anna Lepistö
Jan Böhm
Jukka-Pekka Mecklin
Daniel D. Buchanan
Aung-Ko Win
John Hopper
Mark E. Jenkins
Noralane M. Lindor
Polly A. Newcomb
Steven Gallinger
David Duggan
Graham Casey
Per Hoffmann
Markus M. Nöthen
Karl-Heinz Jöckel
Douglas F. Easton
Paul D. P. Pharoah
Julian Peto
Federico Canzian
Anthony Swerdlow
Rosalind A. Eeles
Zsofia Kote-Jarai
Kenneth Muir
Nora Pashayan
The PRACTICAL consortium
Andrea Harkin
Karen Allan
John McQueen
James Paul
Timothy Iveson
Mark Saunders
Katja Butterbach
Jenny Chang-Claude
Michael Hoffmeister
Hermann Brenner
Iva Kirac
Petar Matošević
Philipp Hofer
Stefanie Brezina
Andrea Gsur
Jeremy P. Cheadle
Lauri A. Aaltonen
Ian Tomlinson
Richard S. Houlston
Malcolm G. Dunlop
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

In colorectal cancer (CRC), finding loci associated with risk may give insight into disease aetiology. Here, the authors report a genome-wide association analysis in Europeans of 34,627 CRC cases and 71,379 controls, and find 31 new risk loci and 17 new risk SNPs at previously reported loci.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.70e8e953edd64bddb89636d55f3bc15c
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-09775-w