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Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression

Authors :
Nicola P. Montaldo
Diana L. Bordin
Alessandro Brambilla
Marcel Rösinger
Sarah L. Fordyce Martin
Karine Øian Bjørås
Stefano Bradamante
Per Arne Aas
Antonia Furrer
Lene C. Olsen
Nicolas Kunath
Marit Otterlei
Pål Sætrom
Magnar Bjørås
Leona D. Samson
Barbara van Loon
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

How genome stability is maintained at regions of active transcription is currently not entirely clear. Here, the authors reveal an association between base excision repair factors and transcription elongation to modulate DNA repair.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.70eb1296de944cc58fe067e2201fa6bb
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-13394-w