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Multilineage-Differentiating Stress-Enduring Cells (Muse Cells): The Future of Human and Veterinary Regenerative Medicine

Authors :
María Gemma Velasco
Katy Satué
Deborah Chicharro
Emma Martins
Marta Torres-Torrillas
Pau Peláez
Laura Miguel-Pastor
Ayla Del Romero
Elena Damiá
Belén Cuervo
José María Carrillo
Ramón Cugat
Joaquín Jesús Sopena
Mónica Rubio
Source :
Biomedicines, Vol 11, Iss 2, p 636 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

In recent years, several studies have been conducted on Muse cells mainly due to their pluripotency, high tolerance to stress, self-renewal capacity, ability to repair DNA damage and not being tumoral. Additionally, since these stem cells can be isolated from different tissues in the adult organism, obtaining them is not considered an ethical problem, providing an advantage over embryonic stem cells. Regarding their therapeutic potential, few studies have reported clinical applications in the treatment of different diseases, such as aortic aneurysm and chondral injuries in the mouse or acute myocardial infarction in the swine, rabbit, sheep and in humans. This review aims to describe the characterization of Muse cells, show their biological characteristics, explain the differences between Muse cells and mesenchymal stem cells, and present their contribution to the treatment of some diseases.

Details

Language :
English
ISSN :
11020636 and 22279059
Volume :
11
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
edsdoj.710eaf0d825d4a55a85fbe76cbb394d1
Document Type :
article
Full Text :
https://doi.org/10.3390/biomedicines11020636