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Synthesis and Anti-tumor Activities of Novel [1,2,4]triazolo[1,5-a]pyrimidines
- Source :
- Molecules, Vol 12, Iss 5, Pp 1136-1146 (2007)
- Publication Year :
- 2007
- Publisher :
- MDPI AG, 2007.
-
Abstract
- A series of novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives has been designed and synthesized in order to find novel anti-tumor compounds. The structures of all the compounds were confirmed by IR, 1H-NMR, MS and elemental analysis. Their anti-tumor activities against cancer cell lines (HT-1080 and Bel-7402) were tested by the MTT method in vitro. Among them, compound 19 displayed the best anti-tumor activity with IC50 values of 12.3 μM and 6.1 μM against Bel-7402 and HT-1080 cell lines respectively.
Details
- Language :
- English
- ISSN :
- 12051136 and 14203049
- Volume :
- 12
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.7169f695ae644bad85d331e45c65093e
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/12051136