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Synthesis and Anti-tumor Activities of Novel [1,2,4]triazolo[1,5-a]pyrimidines

Authors :
Ping Gong
Ding Wang
Hai-Sheng Song
Shu-Chun Guo
Yan-Fang Zhao
Xiang-Lin Zhao
Source :
Molecules, Vol 12, Iss 5, Pp 1136-1146 (2007)
Publication Year :
2007
Publisher :
MDPI AG, 2007.

Abstract

A series of novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives has been designed and synthesized in order to find novel anti-tumor compounds. The structures of all the compounds were confirmed by IR, 1H-NMR, MS and elemental analysis. Their anti-tumor activities against cancer cell lines (HT-1080 and Bel-7402) were tested by the MTT method in vitro. Among them, compound 19 displayed the best anti-tumor activity with IC50 values of 12.3 μM and 6.1 μM against Bel-7402 and HT-1080 cell lines respectively.

Details

Language :
English
ISSN :
12051136 and 14203049
Volume :
12
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.7169f695ae644bad85d331e45c65093e
Document Type :
article
Full Text :
https://doi.org/10.3390/12051136