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Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice

Authors :
Shu Liu
Jianbo Xiu
Caiyun Zhu
Kexin Meng
Chen Li
Rongrong Han
Tingfu Du
Lanlan Li
Lingdan Xu
Renjie Liu
Wanwan Zhu
Yan Shen
Qi Xu
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Post-transcriptional modification of RNA can contribute to regulating behavior. Here, the authors show that modulating the expression of Fto results in epitranscriptomic changes in the mouse hippocampus associated with depression-like behavior.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.71f4d2ea3f6b44e1a1921e645f08bb41
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-27044-7