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Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups

Authors :
Nuzulul Kurniansyah
Matthew O. Goodman
Alyna T. Khan
Jiongming Wang
Elena Feofanova
Joshua C. Bis
Kerri L. Wiggins
Jennifer E. Huffman
Tanika Kelly
Tali Elfassy
Xiuqing Guo
Walter Palmas
Henry J. Lin
Shih-Jen Hwang
Yan Gao
Kendra Young
Gregory L. Kinney
Jennifer A. Smith
Bing Yu
Simin Liu
Sylvia Wassertheil-Smoller
JoAnn E. Manson
Xiaofeng Zhu
Yii-Der Ida Chen
I-Te Lee
C. Charles Gu
Donald M. Lloyd-Jones
Sebastian Zöllner
Myriam Fornage
Charles Kooperberg
Adolfo Correa
Bruce M. Psaty
Donna K. Arnett
Carmen R. Isasi
Stephen S. Rich
Robert C. Kaplan
Susan Redline
Braxton D. Mitchell
Nora Franceschini
Daniel Levy
Jerome I. Rotter
Alanna C. Morrison
Tamar Sofer
Source :
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Abstract We assess performance and limitations of polygenic risk scores (PRSs) for multiple blood pressure (BP) phenotypes in diverse population groups. We compare “clumping-and-thresholding” (PRSice2) and LD-based (LDPred2) methods to construct PRSs from each of multiple GWAS, as well as multi-PRS approaches that sum PRSs with and without weights, including PRS-CSx. We use datasets from the MGB Biobank, TOPMed study, UK biobank, and from All of Us to train, assess, and validate PRSs in groups defined by self-reported race/ethnic background (Asian, Black, Hispanic/Latino, and White). For both SBP and DBP, the PRS-CSx based PRS, constructed as a weighted sum of PRSs developed from multiple independent GWAS, perform best across all race/ethnic backgrounds. Stratified analysis in All of Us shows that PRSs are better predictive of BP in females compared to males, individuals without obesity, and middle-aged (40-60 years) compared to older and younger individuals.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.721f599909e48e7aa862786e05f3dd9
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-023-38990-9