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A nomogram to predict survival in non-small cell lung cancer patients treated with nivolumab

Authors :
Andrea Botticelli
Massimiliano Salati
Francesca Romana Di Pietro
Lidia Strigari
Bruna Cerbelli
Ilaria Grazia Zizzari
Raffaele Giusti
Marco Mazzotta
Federica Mazzuca
Michela Roberto
Patrizia Vici
Laura Pizzuti
Marianna Nuti
Paolo Marchetti
Source :
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-8 (2019)
Publication Year :
2019
Publisher :
BMC, 2019.

Abstract

Abstract Background The advent of immune checkpoint inhibitors (ICIs) has considerably expanded the armamentarium against non-small cell lung cancer (NSCLC) contributing to reshaping treatment paradigms in the advanced disease setting. While promising tissue- and plasma-based biomarkers are under investigation, no reliable predictive factor is currently available to aid in treatment selection. Methods Patients with stage IIIB–IV NSCLC receiving nivolumab at Sant’Andrea Hospital and Regina Elena National Cancer Institute from June 2016 to July 2017 were enrolled onto this study. Major clinicopathological parameters were retrieved and correlated with patients’ survival outcomes in order to assess their prognostic value and build a useful tool to assist in the decision making process. Results A total of 102 patients were included in this study. The median age was 69 years (range 44–85 years), 69 (68%) were male and 52% had ECOG PS 0. Loco-regional/distant lymph nodes were the most commonly involved site of metastasis (71%), followed by lung parenchyma (67%) and bone (26%). Overall survival (OS) in the whole patients’ population was 83.6%, 63.2% and 46.9% at 3, 6 and 12 months, respectively; while progression-free survival (PFS) was 66.5%, 44.4% and 26.4% at 3, 6 and 12 months, respectively. At univariate analysis, age ≥ 69 years (P = 0.057), ECOG PS (P

Details

Language :
English
ISSN :
14795876
Volume :
17
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Translational Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.7233dbb49d41dc850585b62ce3d8ba
Document Type :
article
Full Text :
https://doi.org/10.1186/s12967-019-1847-x