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Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count
- Source :
- Journal of Microbiology, Immunology and Infection, Vol 52, Iss 4, Pp 667-671 (2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137–0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = −0.649, p = 0.020), while no correlation between soluble biomarkers or cellular immune activation was found. Keywords: Exosomes, miRNAs, HIV-1, Elite controllers, Immune activation, Soluble biomarkers
- Subjects :
- Microbiology
QR1-502
Subjects
Details
- Language :
- English
- ISSN :
- 16841182
- Volume :
- 52
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Microbiology, Immunology and Infection
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.725133f9f4b2422c80fc1f2b7486abb8
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jmii.2018.07.007