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Ocular Manifestations of Granulomatosis with Polyangiitis: A Review of the Literature
- Source :
- Ophthalmology and Therapy, Vol 8, Iss 2, Pp 227-234 (2019)
- Publication Year :
- 2019
- Publisher :
- Adis, Springer Healthcare, 2019.
-
Abstract
- Abstract Granulomatosis with polyangiitis (GPA) is a rare systemic autoimmune disease of unknown etiology that is characterized by granulomatous inflammation, tissue necrosis, and vasculitis in small- and medium-sized vessels. Ocular and orbital manifestations are common in almost half of patients with GPA, affecting every structure of the eye, from the eyelid and orbit to the retina, the choroid, and the optic nerve, with a wide range of severity. Since imaging findings are not always specific for the diagnosis of GPA, biopsy is useful to confirm the diagnosis. Regarding treatment, a localized pharmaceutical and surgical approach may be helpful to achieve remission, while immunosuppressive therapy, corticosteroids, and cyclosporine are also useful. In any case, multidisciplinary intervention is required to reduce the rates of relapse and morbidity in patients with GPA.
- Subjects :
- Eye
Diagnosis
Ocular
Orbital
Treatment
Wegener’s
Ophthalmology
RE1-994
Subjects
Details
- Language :
- English
- ISSN :
- 21938245 and 21936528
- Volume :
- 8
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Ophthalmology and Therapy
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.7291ac560834dc5a35a6733da01afd2
- Document Type :
- article
- Full Text :
- https://doi.org/10.1007/s40123-019-0176-8