Back to Search Start Over

Clinical Clues of Pre-Symptomatic Pancreatic Ductal Adenocarcinoma Prior to Its Diagnosis: A Retrospective Review of CT Scans and Laboratory Tests

Authors :
Hwe Hoon Chung
Kyung Sook Lim
Joo Kyung Park
Source :
Clinics and Practice, Vol 12, Iss 1, Pp 70-77 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Most pancreatic ductal adenocarcinoma cases are unresectable at the time of diagnosis. Only early diagnosis and curative resection can help prolong survival. We tried to find out useful clinical clues of pre-symptomatic area prior to pancreatic cancer diagnosis compared to normal controls. Of 4799 patients diagnosed with pancreatic cancer between 1995 and 2014 at the Samsung Medical Center, 51 were selected for study. They had no symptoms at diagnosis and underwent computed tomography 6 to 36 months prior to diagnosis for reasons other than cancer diagnosis. We selected 288 control subjects who underwent computed tomography during the same period. Data were retrospectively reviewed included various variables. Fasting blood sugar (171.8 ± 97.5 vs. 115.8 ± 34.8 units, p < 0.05), new onset diabetes mellitus within 3 years (12/51 (23.5%) vs. 17/181 (9.8%), p < 0.05), carbohydrate antigen 19-9 level (609.5 ± 2342.5 vs. 17.0 ± 26.2, p = 0.08), main pancreatic duct dilatation (26/51 (51.0%) vs. 57/181 (31.5%), p < 0.05) in computed tomography scan were higher in pancreatic cancer group than in normal group, respectively. In multi-variate analysis, carbohydrate antigen 19-9, new onset diabetes mellitus (

Details

Language :
English
ISSN :
20397283
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Clinics and Practice
Publication Type :
Academic Journal
Accession number :
edsdoj.730d029a499940cd8bf0ae2e97fe79b2
Document Type :
article
Full Text :
https://doi.org/10.3390/clinpract12010008