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High grade serous ovarian carcinomas originate in the fallopian tube

Authors :
S. Intidhar Labidi-Galy
Eniko Papp
Dorothy Hallberg
Noushin Niknafs
Vilmos Adleff
Michael Noe
Rohit Bhattacharya
Marian Novak
Siân Jones
Jillian Phallen
Carolyn A. Hruban
Michelle S. Hirsch
Douglas I. Lin
Lauren Schwartz
Cecile L. Maire
Jean-Christophe Tille
Michaela Bowden
Ayse Ayhan
Laura D. Wood
Robert B. Scharpf
Robert Kurman
Tian-Li Wang
Ie-Ming Shih
Rachel Karchin
Ronny Drapkin
Victor E. Velculescu
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

It has previously been proposed that high-grade serous ovarian carcinoma (HGSOC) may originate from the fallopian tube. Here, the authors analyze genetic aberrances in fallopian tube lesions, ovarian cancers, and metastases from HGSOC patients and establish the evolutionary origins of HGSOC in the fallopian tube.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.733833a56c6b45119ce856baf3827bd9
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-017-00962-1