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Inflammatory and Cardiac Biomarkers in Relation with Post-Acute COVID-19 and Mortality: What We Know after Successive Pandemic Waves

Authors :
Catalina Lionte
Victorita Sorodoc
Raluca Ecaterina Haliga
Cristina Bologa
Alexandr Ceasovschih
Ovidiu Rusalim Petris
Adorata Elena Coman
Alexandra Stoica
Oana Sirbu
Gabriela Puha
Mihai Constantin
Gabriela Dumitrescu
Victoria Gorciac
Andrei-Costin Chelariu
Andreea Nicoleta Catana
Elisabeta Jaba
Laurentiu Sorodoc
Source :
Diagnostics, Vol 12, Iss 6, p 1373 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Background: Biomarkers were correlated with mortality in critically ill COVID-19 patients. No prediction tools exist for noncritically ill COVID-19 patients. We aimed to compare the independent prognostic value of inflammation and cardiac biomarkers for post-acute COVID-19 patients and the 30-day mortality rate in noncritically ill COVID-19 patients, as well as the relation with the virus variant involved. Methods: This observational cohort study was conducted at an emergency clinical hospital between 1 October 2020 and 31 December 2021. We included consecutive patients with biomarkers determined within 24 h of presentation, followed up at least 30 days postdischarge. Results: Post-acute COVID-19 was diagnosed in 20.3% of the cases and the all-cause 30-day mortality rate was 35.1% among 978 patients infected with variants of concern. Neutrophil-to-lymphocyte ratio (1.06 [95%CI, 1.01–1.11], p = 0.015) and NT-pro BNP were correlated with 30-daymortality, while the monocyte-to-lymphocyte ratio (2.77 [95%CI, 1.10–6.94], p = 0.03) and NT-pro BNP (1.68 [95%CI, 1.00–2.84], p = 0.05) were correlated with post-acute COVID-19. High-sensitivity to troponin was associated with 30-day mortality (1.55 [95%CI, 1.00–2.42], p = 0.05). A Cox proportional-hazards model confirmed that NT-pro BNP was independently associated with mortality. NT-pro BNP remained independently associated with 30-day mortality during follow-up (1.29 [95%CI, 1.07–1.56], p = 0.007) after adjustment for confounders. Conclusion: Inflammation and cardiac biomarkers, determined upon admission and predischarge, in a cohort of hospitalized noncritically ill COVID-19 patients throughout successive pandemic waves, showed a predictive value for post-acute COVID-19 and 30-day mortality.

Details

Language :
English
ISSN :
20754418
Volume :
12
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Diagnostics
Publication Type :
Academic Journal
Accession number :
edsdoj.7356d6d071074e65aefefc2e3def5ce1
Document Type :
article
Full Text :
https://doi.org/10.3390/diagnostics12061373