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PM00104 (Zalypsis®): A Marine Derived Alkylating Agent

Authors :
Bradley J. Petek
Robin L. Jones
Source :
Molecules, Vol 19, Iss 8, Pp 12328-12335 (2014)
Publication Year :
2014
Publisher :
MDPI AG, 2014.

Abstract

PM00104 (Zalypsis®) is a synthethic tetrahydroisoquinolone alkaloid, which is structurally similar to many marine organisms. The compound has been proposed as a potential chemotherapeutic agent in the treatment of solid human tumors and hematological malignancies. PM00104 is a DNA binding agent, causing inhibition of the cell cycle and transcription, which can lead to double stranded DNA breaks. After rigorous pre-clinical testing, the drug has been evaluated in a number of phase II clinical trials. This manuscript provides a review of current trials and appraises the efficacy of PM00104 as a future cancer treatment.

Details

Language :
English
ISSN :
14203049
Volume :
19
Issue :
8
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.740d584bf974e0ea6f6f610da74781c
Document Type :
article
Full Text :
https://doi.org/10.3390/molecules190812328