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Changes of 1,5-AG in Vitreous Humor of Rabbit Cadavers with Hyperglycemic Metabolism
- Source :
- Fayixue Zazhi, Vol 39, Iss 1, Pp 13-17 (2023)
- Publication Year :
- 2023
- Publisher :
- Editorial Office of Journal of Forensic Medicine, 2023.
-
Abstract
- ObjectiveTo investigate the concentration and change characteristics of 1,5-anhydroglucitol (1,5-AG) in the vitreous humor of rabbit cadavers with hyperglycemic metabolism, and to explore the value of 1,5-AG in forensic pathology identification of death caused by hyperglycemic metabolism disorders.MethodsA diabetic hyperglycemic rabbit model was established by using alloxan. Eighteen rabbits with fasting glucose concentration ≥13.80 mmol/L (experimental group) and 18 healthy rabbits with fasting glucose concentration ≤6.10 mmol/L (control group) were selected. After death from air embolism. The blood samples were collected immediately, and vitreous humor samples were collected at 0 h, 12 h, 24 h and 36 h after death. The concentration of 1,5-AG in the blood and vitreous humor of rabbits was determined.ResultsThe blood glucose concentration in the experimental group was (25.10±3.14) mmol/L. At the time of death, there was no significant difference in the concentration of 1,5-AG in the blood [(0.94±0.20) μg/mL] and in the vitreous humor (0.99±0.05 μg/mL, P>0.05). The concentration of 1,5-AG in the vitreous humor of the experimental group was lower than that of the corresponding control group at all time points (P0.05). Correlation analysis showed that the concentration of 1,5-AG in blood was negatively correlated with blood glucose in both control group and experimental group (control group: r=-0.79, P
Details
- Language :
- Chinese
- ISSN :
- 10045619
- Volume :
- 39
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Fayixue Zazhi
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.74263ddb9b646948245ae4e06da164a
- Document Type :
- article
- Full Text :
- https://doi.org/10.12116/j.issn.1004-5619.2021.410403