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A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice

Authors :
Carl-Philipp Hackstein
Dana Costigan
Linnea Drexhage
Claire Pearson
Samuel Bullers
Nicholas Ilott
Hossain Delowar Akther
Yisu Gu
Michael E. B. FitzPatrick
Oliver J. Harrison
Lucy C. Garner
Elizabeth H. Mann
Sumeet Pandey
Matthias Friedrich
Nicholas M. Provine
Holm H. Uhlig
Emanuele Marchi
Fiona Powrie
Paul Klenerman
Emily E. Thornton
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Interactions between the host immune response and the commensal microbiota play essential roles in health and disease. Here the authors identify a population of MHC class II, innate like, commensal reactive cells in the gut of mice and humans.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.7533503d8e2b41c48a9f686bb5ff0167
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-35126-3