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Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs
- Source :
- Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Portfolio, 2019.
-
Abstract
- Control of CRISPR-Cas9 activity allows for fine-tuning of editing and gene expression. Here the authors use gRNAs modified with RNA aptamers to enable small molecule control in bacterial systems.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.75a198d8f2ba47a985055e98863b4ffd
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-019-09985-2