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Comparison of deep inspiration breath hold and free breathing intensity modulated proton therapy of locally advanced lung cancer
- Source :
- Physics and Imaging in Radiation Oncology, Vol 30, Iss , Pp 100590- (2024)
- Publication Year :
- 2024
- Publisher :
- Elsevier, 2024.
-
Abstract
- Background and purpose: For locally advanced non-small cell lung cancer (LA-NSCLC), intensity-modulated proton therapy (IMPT) can reduce organ at risk (OAR) doses compared to intensity-modulated radiotherapy (IMRT). Deep inspiration breath hold (DIBH) reduces OAR doses compared to free breathing (FB) in IMRT. In IMPT, differences in dose distributions and robustness between DIBH and FB are unclear. In this study, we compare DIBH to FB in IMPT, and IMPT to IMRT. Materials and methods: Fortyone LA-NSCLC patients were prospectively included. 4D computed tomography images (4DCTs) and DIBH CTs were acquired for treatment planning and during weeks 1 and 3 of treatment. A new system for automated robust planning was developed and used to generate a FB and a DIBH IMPT plan for each patient. Plans were compared in terms of dose-volume parameters and normal tissue complication probabilities (NTCPs). Dose recalculations on repeat CTs were used to compare inter-fraction plan robustness. Results: In IMPT, DIBH reduced median lungs Dmean from 9.3 Gy(RBE) to 8.0 Gy(RBE) compared to FB, and radiation pneumonitis NTCP from 10.9 % to 9.4 % (p
- Subjects :
- Deep inspiration breath hold (DIBH)
Lung cancer radiotherapy
Radiotherapy robustness
Radiation toxicity
Normal tissue complication probability (NTCP)
Autoplanning
Medical physics. Medical radiology. Nuclear medicine
R895-920
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Subjects
Details
- Language :
- English
- ISSN :
- 24056316 and 71690646
- Volume :
- 30
- Issue :
- 100590-
- Database :
- Directory of Open Access Journals
- Journal :
- Physics and Imaging in Radiation Oncology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.76637a716906460293b2b37acf1ae933
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.phro.2024.100590