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Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy
- Source :
- Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
- Publication Year :
- 2018
- Publisher :
- Nature Portfolio, 2018.
-
Abstract
- Brain tumours are associated with epilepsy. Here the authors show, using a mouse model, that the degradation of perineuronal nets around fast spiking interneurons near the tumour contribute to seizures by increasing their membrane capacitance and firing.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 9
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.76ee429c0d5743bdbdf32e9dfbd740e1
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-018-07113-0