High-sulforaphane broccoli sprout powder reduces serum nitric oxide metabolites in Helicobacter pylori infected patients

Pathological over production of nitric oxide (NO), induced by Helicobacter pylori, has been known as a risk factor for development of gastritis and gastric cancer. The current study investigated the effect of high-sulforaphane (SFN) broccoli sprouts powder on serum NO metabolites in H. pylori infected patients. Eighty-six patients with positive H. pylori stool antigen test (HpSAg) were randomized to receive one of the three following regimens: Standard triple therapy (STT) for 14 days, 6 g/d broccoli sprouts powder (BSP) for 28 days, and combination of these as STT (for 14 days) + BSP (for 28 days). Fasting serum NO metabolites were assessed at baseline and again after treatment. There was a significant decrease in serum NOx levels in BSP (25.2 vs. 51.6 μmol/L, P