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Endogenous Human Proteins Interfering with Amyloid Formation

Authors :
Anna L. Gharibyan
Sanduni Wasana Jayaweera
Manuela Lehmann
Intissar Anan
Anders Olofsson
Source :
Biomolecules, Vol 12, Iss 3, p 446 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Amyloid formation is a pathological process associated with a wide range of degenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and diabetes mellitus type 2. During disease progression, abnormal accumulation and deposition of proteinaceous material are accompanied by tissue degradation, inflammation, and dysfunction. Agents that can interfere with the process of amyloid formation or target already formed amyloid assemblies are consequently of therapeutic interest. In this context, a few endogenous proteins have been associated with an anti-amyloidogenic activity. Here, we review the properties of transthyretin, apolipoprotein E, clusterin, and BRICHOS protein domain which all effectively interfere with amyloid in vitro, as well as displaying a clinical impact in humans or animal models. Their involvement in the amyloid formation process is discussed, which may aid and inspire new strategies for therapeutic interventions.

Details

Language :
English
ISSN :
2218273X
Volume :
12
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Biomolecules
Publication Type :
Academic Journal
Accession number :
edsdoj.7703cc0dc6d1447a8bfe02d82a32ec87
Document Type :
article
Full Text :
https://doi.org/10.3390/biom12030446