Analgesic effect of Jasminum sambac hydro alcoholic extract in rats: role of the GABAergic and opioidergic pathways

Background and Aim: There are several reports about analgesic, anti-depressant, anti-inflammatory, antiseptic, sedative, and anti-spasmodic effects of Jasminum sambac. The aim of this study was to investigate the analgesic effects of Jasminum sambac hydroalcoholic extract and determine the role of GABAergic and opioidergic pathways in rat model by a plantar device. Material and Methods: Wistar male rats were randomly divided into six groups (n=6) including control, the groups treated with hydroalcoholic extract of Jasminum Sambac (100, 200, 400, mg/kg, ip) and the groups which received the most effective dose of the extract in addition to naloxone or flumazenil. The analgesic effect was assessed by plantar device after 30, 60 and 90 min of the injections. Results: Our results showed that injection of hydroalcoholic extract of Jasminum sambac (200 mg/kg, ip) increased significantly the time delay in response to thermal pain inducing effect at 30, 60 and 90 (P