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Secreted Non-Coding RNAs: Functional Impact on the Tumor Microenvironment and Clinical Relevance in Triple-Negative Breast Cancer

Authors :
Silvia Di Agostino
Mahrou Vahabi
Chiara Turco
Giulia Fontemaggi
Source :
Non-Coding RNA, Vol 8, Iss 1, p 5 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Triple-negative breast cancer (TNBC) is a subtype of breast carcinoma characterized by poor prognosis and high rate of metastasis. Current treatment is based on chemo- and/or radiotherapy and surgery. TNBC is devoid of estrogen, progesterone and HER2 receptors. Although precision medicine has come a long way to ameliorate breast cancer disease management, targeted therapies for the treatment of TNBC patients are still limited. Mounting evidence has shown that non-coding RNAs (ncRNAs) drive many oncogenic processes at the basis of increased proliferation, invasion and angiogenesis in TNBC, strongly contributing to tumor progression and resistance to treatments. Many of these ncRNAs are secreted in the tumor microenvironment (TME) and impinge on the activity of the diverse immune and stromal cell types infiltrating the TME. Importantly, secreted ncRNAs may be detected as circulating molecules in serum/plasma from cancer patients and are emerging a promising diagnostic/therapeutic tools in TNBC. This review aims to discuss novel insights about the role of secreted circulating ncRNAs in the intercellular communication in the tumor microenvironment and their potential clinical use as diagnostic and prognostic non-invasive biomarkers in TNBC.

Details

Language :
English
ISSN :
2311553X
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Non-Coding RNA
Publication Type :
Academic Journal
Accession number :
edsdoj.773f4a086d40cea461bcba519370cc
Document Type :
article
Full Text :
https://doi.org/10.3390/ncrna8010005