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Generation of Whole-Genome Sequencing Data for Comparing Primary and Castration-Resistant Prostate Cancer
- Source :
- Genomics & Informatics, Vol 16, Iss 3, Pp 71-74 (2018)
- Publication Year :
- 2018
- Publisher :
- Korea Genome Organization, 2018.
-
Abstract
- Because castration-resistant prostate cancer (CRPC) does not respond to androgen deprivation therapy and has a very poor prognosis, it is critical to identify a prognostic indicator for predicting high-risk patients who will develop CRPC. Here, we report a dataset of whole genomes from four pairs of primary prostate cancer (PC) and CRPC samples. The analysis of the paired PC and CRPC samples in the whole-genome data showed that the average number of somatic mutations per patients was 7,927 in CRPC tissues compared with primary PC tissues (range, 1,691 to 21,705). Our whole-genome sequencing data of primary PC and CRPC may be useful for understanding the genomic changes and molecular mechanisms that occur during the progression from PC to CRPC.
Details
- Language :
- English
- ISSN :
- 22340742
- Volume :
- 16
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Genomics & Informatics
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.77aa0f071ab54bf380310dec61268e6e
- Document Type :
- article
- Full Text :
- https://doi.org/10.5808/GI.2018.16.3.71