Development history of cerebral autoregulation

Cerebral autoregulation (CA) refers to the ability to maintain cerebral blood flow (CBF) relatively constant under the condition of systemic arterial blood pressure (ABP) fluctuation. Up to now, the research on the function of CA has a history of nearly 100 years. From animal models to noninvasive real ⁃ time human hemodynamic monitoring, progress of detecting techniques, especially the wide application of transcranial Doppler ultrasonography (TCD) and the introduction of mathematical methods have brought revolutionary changes to the study of CA. This study aims to summarize the development history of mechanism of CA and detecting techniques, and to provide reference for the related clinical study.