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Decorated CuO nanoparticles over chitosan-functionalized magnetic nanoparticles: Investigation of its anti-colon carcinoma and anti-gastric cancer effects
- Source :
- Arabian Journal of Chemistry, Vol 14, Iss 7, Pp 103201- (2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- In this study, a green protocol for supporting CuO nanoparticles over chitosan-modified amino-magnetic nanoparticles is described. The physicochemical and morphological properties of the desired nanocomposite assessed by various techniques like ICP, FT-IR, FE-SEM, EDX, TEM, XRD and VSM. In the oncological part of the recent study, the Cu(NO3)2, Fe3O4, and Fe3O4-NH2@CS/CuO nanocomposite cell viability was very low against human gastric cancer cell lines i.e. MKN45, AGS, and KATO III and human colorectal carcinoma cell lines i.e. HT-29, HCT 116, HCT-8 [HRT-18], and Ramos.2G6.4C10. The IC50 of Fe3O4-NH2@CS/CuO nanocomposite against MKN45, AGS, KATO III, HT-29, HCT 116, HCT-8 [HRT-18], and Ramos.2G6.4C10 cell lines were 517, 525, 544, 282, 214, 420, and 477 µg/mL, respectively. Thereby, the best anti-gastro-duodenal cancers findings of our Fe3O4-NH2@CS/CuO nanocomposite was seen in the HCT 116 cell line case.
Details
- Language :
- English
- ISSN :
- 18785352
- Volume :
- 14
- Issue :
- 7
- Database :
- Directory of Open Access Journals
- Journal :
- Arabian Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.77eae7981e754a43aaa8af3e54c059d7
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.arabjc.2021.103201