Evaluation of Post-Infectious Glomerulonephritis: Single Center Experience

Aim: Post-infectious glomerulonephritis (PIGN) is an acute glomerulonephritis, often develops after infections with nephritogenic strains of group A beta hemolytic streptococcus. Patients may present with mild findings such as asymptomatic microscopic hematuria and non-nephrotic proteinuria or they may present with severe findings such as macroscopic hematuria, nephrotic range proteinuria, edema, hypertension, and acute kidney injury. In this paper, we aimed to present the laboratory and clinical findings of patients who applied to pediatric nephrology clinic in a short period of six months and were followed up with the diagnosis of PIGN. Materials and Methods: The medical records of 30 patients who were followed up in Adana City Training and Research Hospital with the diagnosis of PIGN in a six-month period (between October 2022 and March 2023) were evaluated retrospectively. The clinical, laboratory and treatment data of the patients were recorded. Results: Acute nephritic syndrome was the most common clinical presentation with 22 patients (73.3%) followed up with PIGN. Four (13.3%) of the patients presented with nephrotic syndrome, two (6.7%) with rapidly progressive glomerulonephritis, and two (%6.7) with hypertensive encephalopathy. Kidney biopsy was performed in 3 patients, two of whom presented with rapidly progressive glomerulonephritis and one whose complement 3 level remained low beyond 8 weeks. The pathological diagnosis of these patients was reported as diffuse proliferative glomerulonephritis. Conclusion: Although PIGN usually occurs as a benign nephritis, it should be kept in mind that patients whose diagnosis is delayed and not treated appropriately may present with poor clinical