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Development of an antibody fragment that stabilizes GPCR/G-protein complexes
- Source :
- Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
- Publication Year :
- 2018
- Publisher :
- Nature Portfolio, 2018.
-
Abstract
- The determination of high resolution structures of G protein coupled receptors (GPCRs) in complex with heterotrimeric G proteins is challenging. Here authors develop an antibody fragment, mAB16, which stabilizes GPCR/G-protein complexes and facilitates the application of high resolution cryo-EM.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723 and 78767849
- Volume :
- 9
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.78767849a46d4536a969df36dd817784
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-018-06002-w