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MnSOD Val16Ala polymorphism associated with retinopathy risk in diabetes: a PRISMA-compliant Meta-analysis of case-control studies
- Source :
- International Journal of Ophthalmology, Vol 10, Iss 4, Pp 639-645 (2017)
- Publication Year :
- 2017
- Publisher :
- Press of International Journal of Ophthalmology (IJO PRESS), 2017.
-
Abstract
- AIM: To investigate the association of Manganese superoxide dismutase (MnSOD) Val16Ala polymorphism with diabetic retinopathy (DR). METHODS: PubMed, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association. Subgroup, sensitivity, and cumulative analyses were performed. Publication bias was also analyzed. RESULTS: Eight studies were included in the pooled analysis. The MnSOD Val16Ala polymorphism was associated with the risk of DR under the dominant model (OR=0.66, 95%CI=0.48-0.91, P
- Subjects :
- 645
diabetic
retinopathy
MnSOD
Val16Ala
Ophthalmology
RE1-994
Subjects
Details
- Language :
- English
- ISSN :
- 22223959 and 22274898
- Volume :
- 10
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- International Journal of Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.789d73cdd67e4479be1ee1909c57f977
- Document Type :
- article
- Full Text :
- https://doi.org/10.18240/ijo.2017.04.22