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The roles of neutrophils in non-tuberculous mycobacterial pulmonary disease

Authors :
Meyad Alkarni
Marc Lipman
David M. Lowe
Source :
Annals of Clinical Microbiology and Antimicrobials, Vol 22, Iss 1, Pp 1-12 (2023)
Publication Year :
2023
Publisher :
BMC, 2023.

Abstract

Abstract Non-tuberculous Mycobacterial Pulmonary Disease (NTM-PD) is an increasingly recognised global health issue. Studies have suggested that neutrophils may play an important role in controlling NTM infection and contribute to protective immune responses within the early phase of infection. However, these cells are also adversely associated with disease progression and exacerbation and can contribute to pathology, for example in the development of bronchiectasis. In this review, we discuss the key findings and latest evidence regarding the diverse functions of neutrophils in NTM infection. First, we focus on studies that implicate neutrophils in the early response to NTM infection and the evidence reporting neutrophils’ capability to kill NTM. Next, we present an overview of the positive and negative effects that characterise the bidirectional relationship between neutrophils and adaptive immunity. We consider the pathological role of neutrophils in driving the clinical phenotype of NTM-PD including bronchiectasis. Finally, we highlight the current promising treatments in development targeting neutrophils in airways diseases. Clearly, more insights on the roles of neutrophils in NTM-PD are needed in order to inform both preventative strategies and host-directed therapy for these important infections.

Details

Language :
English
ISSN :
14760711
Volume :
22
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Annals of Clinical Microbiology and Antimicrobials
Publication Type :
Academic Journal
Accession number :
edsdoj.78beef11bdc74f4b964acad06646c439
Document Type :
article
Full Text :
https://doi.org/10.1186/s12941-023-00562-6