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Vibrio cholerae senses human enteric α-defensin 5 through a CarSR two-component system to promote bacterial pathogenicity

Authors :
Yutao Liu
Tingting Xu
Qian Wang
Junxi Huang
Yangfei Zhu
Xingmei Liu
Ruiying Liu
Bin Yang
Kai Zhou
Source :
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

The antimicrobial peptide human defensin-5 (HD-5) is found to upregulate Vibrio cholera virulence genes in a manner dependent on the two-component system, CarSR, providing insights into how the cholera pathogen responds to intestinal HD-5.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
5
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.78d9dcc981a4750b5d4976fc49f867b
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-022-03525-3