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A comparative study of treatment of cervical low-grade squamous intraepithelial lesions (LSIL)

Authors :
Yi Chen
Zhangli Dong
Lirong Yuan
Ying Xu
Dan Cao
Zhenhong Xiong
Zhengrong Zhang
Dan Wu
Source :
Photodiagnosis and Photodynamic Therapy, Vol 45, Iss , Pp 103920- (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

Background and Aims: Low-grade squamous intraepithelial lesion (LSIL) is one of two categories of cervical intraepithelial lesions. Given that controversy exists regarding its management, this comparative study aimed to evaluate the effect of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in treating LSIL of the high-risk human papillomavirus (HR-HPV)-infected cervix. Methods: A total of 218 patients (25–45 years old) with cervical LSIL associated with HR-HPV who underwent ALA-PDT, loop electrosurgical excision procedure (LEEP), or observation only were included. The clearance rates of cervical LSIL and HR-HPV between the ALA-PDT, LEEP, and observation groups were compared at 6 and 12 months follow-up. Adverse reactions were also compared. The factors affecting the clearance on ALA-PDT of cervical LSIL were evaluated. Results: There were no statistically significant differences in lesion and HR-HPV clearance rates between the ALA-PDT and LEEP groups at 6 and 12 months. However, the lesion and HR-HPV clearance rates were significantly higher in the ALA-PDT group than that in the observation group. The adverse reaction rate was significantly lower in the ALA-PDT group than in the LEEP group. Conclusion: For patients with cervical LSIL, the lesion and HR-HPV clearance rates after ALA-PDT were close to those after LEEP and significantly higher than in the observation group. Moreover, the adverse reaction rate for ALA-PDT was much lower than that for LEEP. Therefore, ALA-PDT provides a new option for the minimally invasive treatment of cervical LSIL.

Details

Language :
English
ISSN :
15721000
Volume :
45
Issue :
103920-
Database :
Directory of Open Access Journals
Journal :
Photodiagnosis and Photodynamic Therapy
Publication Type :
Academic Journal
Accession number :
edsdoj.78e8a88201984b08b0896503c30efb08
Document Type :
article
Full Text :
https://doi.org/10.1016/j.pdpdt.2023.103920