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Factor VIII: Perspectives on Immunogenicity and Tolerogenic Strategies

Authors :
David W. Scott
Kathleen P. Pratt
Source :
Frontiers in Immunology, Vol 10 (2020)
Publication Year :
2020
Publisher :
Frontiers Media S.A., 2020.

Abstract

Therapeutic treatment of bleeds with FVIII can lead to an antibody response that effectively inhibits its function. Herein, we review the factors that contribute to this immunogenicity and possible ways to overcome it.

Subjects

Subjects :
factor VIII
tolerance
hemophilia
inhibitors
regulatory T (Treg) cells
Immunologic diseases. Allergy
RC581-607

Details

Language :
English
ISSN :
16643224
Volume :
10
Database :
Directory of Open Access Journals
Journal :
Frontiers in Immunology
Publication Type :
Academic Journal
Accession number :
edsdoj.78f5db4367584eaea2877a31cd0f5eed
Document Type :
article
Full Text :
https://doi.org/10.3389/fimmu.2019.03078
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