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Group 2 Innate Lymphoid Cells Exacerbate Amebic Liver Abscess in Mice
- Source :
- iScience, Vol 23, Iss 9, Pp 101544- (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Summary: Entamoeba histolytica, a protozoan parasite in the lumen of the human large intestine, occasionally spreads to the liver and induces amebic liver abscesses (ALAs). Upon infection with E. histolytica, high levels of type 2 cytokines are induced in the liver early after infection. However, the sources and functions of these initial type 2 cytokines in ALA formation remain unclear. In this study, we examined the roles of group 2 innate lymphoid cells (ILC2s) in ALA formation. Hepatic ILC2 numbers were significantly increased and they produced robust levels of IL-5. The in vivo transfer of ILC2s into Rag2−/−common γ chain (γc)−/− KO mice aggravated ALA formation accompanied by eosinophilia and neutrophilia. Furthermore, IL-33-deficient mice and IL-5-neutralized mice had less ALA formations. These results suggest that ILC2s contribute to exacerbating the pathogenesis of ALA by producing early type 2 cytokines and promoting the accumulation of eosinophils and neutrophils in the liver.
- Subjects :
- Immunology
Microbiology
Microbiology Parasite
Science
Subjects
Details
- Language :
- English
- ISSN :
- 25890042
- Volume :
- 23
- Issue :
- 9
- Database :
- Directory of Open Access Journals
- Journal :
- iScience
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.78febbebdfd9468193c183014ba554c2
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.isci.2020.101544