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Sex, Prescribing Practices and Guideline Recommended, Blood Pressure, and LDL Cholesterol Targets at Baseline in the BARI 2D Trial

Authors :
Michelle F. Magee
Jacqueline E. Tamis-Holland
Jiang Lu
Vera A. Bittner
Maria Mori Brooks
Neuza Lopes
Alice K. Jacobs
BARI 2D Study Group
Source :
International Journal of Endocrinology, Vol 2015 (2015)
Publication Year :
2015
Publisher :
Wiley, 2015.

Abstract

Background. Research has shown less aggressive treatment and poorer control of cardiovascular disease (CVD) risk factors in women than men. Methods. We analyzed sex differences in pharmacotherapy strategies and attainment of goals for hemoglobin A1c (HbA1c), blood pressure (BP), and low density lipoprotein cholesterol (LDL-C) in patients with type 2 diabetes and established coronary artery disease enrolled into the BARI 2D trial. Results. Similar numbers of drugs were prescribed in both women and men. Women were less frequent on metformin or sulfonylurea and more likely to take insulin and to be on higher doses of hydroxymethylglutaryl-CoA reductase inhibitors (statins) than men. After adjusting for baseline differences and treatment prescribed, women were less likely to achieve goals for HbA1c (OR = 0.71, 95% CI 0.57, 0.88) and LDL-C (OR = 0.64, 95% CI 0.53, 0.78). More antihypertensives were prescribed to women, and yet BP ≤ 130/80 mmHg did not differ by sex. Conclusions. Women entering the BARI 2D trial were as aggressively treated with drugs as men. Despite equivalent treatment, women less frequently met targets for HbA1c and LDL-C. Our findings suggest that there may be sex differences in response to drug therapies used to treat diabetes, hypertension, and hyperlipidemia.

Details

Language :
English
ISSN :
16878337 and 16878345
Volume :
2015
Database :
Directory of Open Access Journals
Journal :
International Journal of Endocrinology
Publication Type :
Academic Journal
Accession number :
edsdoj.791da64834d49de9382167f307aaa51
Document Type :
article
Full Text :
https://doi.org/10.1155/2015/610239