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A case of epidermolytic palmoplantar keratosis caused by KRT9 mutation
- Source :
- Pifu-xingbing zhenliaoxue zazhi, Vol 29, Iss 1, Pp 34-36 (2022)
- Publication Year :
- 2022
- Publisher :
- editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology, 2022.
-
Abstract
- A case of epidermolytic palmoplantar keratosis caused by KRT9 mutation is reported. A 32-year-old Chinese man presented with a 30-year history of palmoplantar hyperkeratotic plaques. Dermatological examination showed the hyperkeratotic plaques on bilateral palms and soles, and rough thickened skin in gray-yellow color. The histopathology revealed markedly epidermolytic hyperkeratosis, acanthosis and vacuolar changes of the stratum granulosum. Whole-exome sequencing showed a exon mutation of KRT9 gene [c. 487C>T (p. Arg163Trp) ]. The patient was diagnosed as epidermolytic palmoplantar keratosis.
- Subjects :
- epidermolytic
palmoplantar keratoderma
krt9 gene
Dermatology
RL1-803
Subjects
Details
- Language :
- Chinese
- ISSN :
- 16748468
- Volume :
- 29
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Pifu-xingbing zhenliaoxue zazhi
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.792748f177b454bbe3c837dcc29d08c
- Document Type :
- article
- Full Text :
- https://doi.org/10.3969/j.issn.1674-8468.2022.01.007