Back to Search Start Over

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Authors :
Vasiliki Lagou
Reedik Mägi
Jouke- Jan Hottenga
Harald Grallert
John R. B. Perry
Nabila Bouatia-Naji
Letizia Marullo
Denis Rybin
Rick Jansen
Josine L. Min
Antigone S. Dimas
Anna Ulrich
Liudmila Zudina
Jesper R. Gådin
Longda Jiang
Alessia Faggian
Amélie Bonnefond
Joao Fadista
Maria G. Stathopoulou
Aaron Isaacs
Sara M. Willems
Pau Navarro
Toshiko Tanaka
Anne U. Jackson
May E. Montasser
Jeff R. O’Connell
Lawrence F. Bielak
Rebecca J. Webster
Richa Saxena
Jeanette M. Stafford
Beate St Pourcain
Nicholas J. Timpson
Perttu Salo
So-Youn Shin
Najaf Amin
Albert V. Smith
Guo Li
Niek Verweij
Anuj Goel
Ian Ford
Paul C. D. Johnson
Toby Johnson
Karen Kapur
Gudmar Thorleifsson
Rona J. Strawbridge
Laura J. Rasmussen-Torvik
Tõnu Esko
Evelin Mihailov
Tove Fall
Ross M. Fraser
Anubha Mahajan
Stavroula Kanoni
Vilmantas Giedraitis
Marcus E. Kleber
Günther Silbernagel
Julia Meyer
Martina Müller-Nurasyid
Andrea Ganna
Antti-Pekka Sarin
Loic Yengo
Dmitry Shungin
Jian’an Luan
Momoko Horikoshi
Ping An
Serena Sanna
Yvonne Boettcher
N. William Rayner
Ilja M. Nolte
Tatijana Zemunik
Erik van Iperen
Peter Kovacs
Nicholas D. Hastie
Sarah H. Wild
Stela McLachlan
Susan Campbell
Ozren Polasek
Olga Carlson
Josephine Egan
Wieland Kiess
Gonneke Willemsen
Johanna Kuusisto
Markku Laakso
Maria Dimitriou
Andrew A. Hicks
Rainer Rauramaa
Stefania Bandinelli
Barbara Thorand
Yongmei Liu
Iva Miljkovic
Lars Lind
Alex Doney
Markus Perola
Aroon Hingorani
Mika Kivimaki
Meena Kumari
Amanda J. Bennett
Christopher J. Groves
Christian Herder
Heikki A. Koistinen
Leena Kinnunen
Ulf de Faire
Stephan J. L. Bakker
Matti Uusitupa
Colin N. A. Palmer
J. Wouter Jukema
Naveed Sattar
Anneli Pouta
Harold Snieder
Eric Boerwinkle
James S. Pankow
Patrik K. Magnusson
Ulrika Krus
Chiara Scapoli
Eco J. C. N. de Geus
Matthias Blüher
Bruce H. R. Wolffenbuttel
Michael A. Province
Goncalo R. Abecasis
James B. Meigs
G. Kees Hovingh
Jaana Lindström
James F. Wilson
Alan F. Wright
George V. Dedoussis
Stefan R. Bornstein
Peter E. H. Schwarz
Anke Tönjes
Bernhard R. Winkelmann
Bernhard O. Boehm
Winfried März
Andres Metspalu
Jackie F. Price
Panos Deloukas
Antje Körner
Timo A. Lakka
Sirkka M. Keinanen-Kiukaanniemi
Timo E. Saaristo
Richard N. Bergman
Jaakko Tuomilehto
Nicholas J. Wareham
Claudia Langenberg
Satu Männistö
Paul W. Franks
Caroline Hayward
Veronique Vitart
Jaakko Kaprio
Sophie Visvikis-Siest
Beverley Balkau
David Altshuler
Igor Rudan
Michael Stumvoll
Harry Campbell
Cornelia M. van Duijn
Christian Gieger
Thomas Illig
Luigi Ferrucci
Nancy L. Pedersen
Peter P. Pramstaller
Michael Boehnke
Timothy M. Frayling
Alan R. Shuldiner
Patricia A. Peyser
Sharon L. R. Kardia
Lyle J. Palmer
Brenda W. Penninx
Pierre Meneton
Tamara B. Harris
Gerjan Navis
Pim van der Harst
George Davey Smith
Nita G. Forouhi
Ruth J. F. Loos
Veikko Salomaa
Nicole Soranzo
Dorret I. Boomsma
Leif Groop
Tiinamaija Tuomi
Albert Hofman
Patricia B. Munroe
Vilmundur Gudnason
David S. Siscovick
Hugh Watkins
Cecile Lecoeur
Peter Vollenweider
Anders Franco-Cereceda
Per Eriksson
Marjo-Riitta Jarvelin
Kari Stefansson
Anders Hamsten
George Nicholson
Fredrik Karpe
Emmanouil T. Dermitzakis
Cecilia M. Lindgren
Mark I. McCarthy
Philippe Froguel
Marika A. Kaakinen
Valeriya Lyssenko
Richard M. Watanabe
Erik Ingelsson
Jose C. Florez
Josée Dupuis
Inês Barroso
Andrew P. Morris
Inga Prokopenko
Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC)
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Sex differences in fasting glucose and insulin have been identified, but the genetic loci underlying these differences have not. Here, the authors perform a meta-analysis of genome-wide association studies to detect sex-specific and sex-dimorphic loci associated with fasting glucose and insulin.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.7959f93136b14448a7811855feb4fcf6
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-19366-9