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Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies

Authors :
Rajkumar Dorajoo
Xuling Chang
Resham Lal Gurung
Zheng Li
Ling Wang
Renwei Wang
Kenneth B. Beckman
Jennifer Adams-Haduch
Yiamunaa M
Sylvia Liu
Wee Yang Meah
Kar Seng Sim
Su Chi Lim
Yechiel Friedlander
Jianjun Liu
Rob M. van Dam
Jian-Min Yuan
Woon-Puay Koh
Chiea Chuen Khor
Chew-Kiat Heng
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

Shortening of leukocyte telomere length (LTL) is associated with age and increased risk for various chronic diseases. Here, the authors report genome-wide association studies for LTL in Singaporean Chinese populations and find that longer LTL associates with less severe outcomes of respiratory disease phenotypes.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.798819afb9664632abd7ea8734efd972
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-10443-2