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Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation

Authors :
Kai P. Hoefig
Alexander Reim
Christian Gallus
Elaine H. Wong
Gesine Behrens
Christine Conrad
Meng Xu
Lisa Kifinger
Taku Ito-Kureha
Kyra A. Y. Defourny
Arie Geerlof
Josef Mautner
Stefanie M. Hauck
Dirk Baumjohann
Regina Feederle
Matthias Mann
Michael Wierer
Elke Glasmacher
Vigo Heissmeyer
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

An extensive RNA binding protein atlas (RBPome) for primary T cells would be a useful resource. Here the authors use two different methods to characterise the mouse and human T cell RBPome and show regulation of Roquin-1/2 dependent and independent pathways.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.79f61fbb2db9463391f56fc5ab732e2e
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-25345-5