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Update on the mechanism of microglia involvement in post-stroke cognitive impairment

Authors :
Tianxiang Zeng
Jun Liu
Wenjun Zhang
Yanyan Yu
Xinyun Ye
Qianliang Huang
Peng Li
Qiuhua Jiang
Source :
Frontiers in Aging Neuroscience, Vol 16 (2024)
Publication Year :
2024
Publisher :
Frontiers Media S.A., 2024.

Abstract

Post-stroke cognitive impairment (PSCI) is a clinical syndrome characterized by cognitive deficits that manifest following a stroke and persist for up to 6 months post-event. This condition is grave, severely compromising patient quality of life and longevity, while also imposing substantial economic burdens on societies worldwide. Despite significant advancements in identifying risk factors for PSCI, research into its underlying mechanisms and therapeutic interventions remains inadequate. Microglia, the brain’s primary immune effector cells, are pivotal in maintaining, nurturing, defending, and repairing neuronal function, a process intrinsically linked to PSCI’s progression. Thus, investigating microglial activation and mechanisms in PSCI is crucial. This paper aims to foster new preventive and therapeutic approaches for PSCI by elucidating the roles, mechanisms, and characteristics of microglia in the condition.

Details

Language :
English
ISSN :
16634365
Volume :
16
Database :
Directory of Open Access Journals
Journal :
Frontiers in Aging Neuroscience
Publication Type :
Academic Journal
Accession number :
edsdoj.7a0638b8778a48dc94db0fb1ca92cdb1
Document Type :
article
Full Text :
https://doi.org/10.3389/fnagi.2024.1366710