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DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain

Authors :
Jing Zhang
Marina A. Bellani
Ryan C. James
Durga Pokharel
Yongqing Zhang
John J. Reynolds
Gavin S. McNee
Andrew P. Jackson
Grant S. Stewart
Michael M. Seidman
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

Eukaryotic replisomes are multiprotein complexes. Here the authors reveal two distinct stressed replisomes, associated with DONSON and FANCM, displaying a bias in replication timing and chromatin domain.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.7a82d16e8a04937bed09a5543ead4cb
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-17449-1