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Association of APOE genotype with carotid atherosclerosis in men and women

Authors :
Roberto Elosua
Jose M. Ordovas
L. Adrienne Cupples
Caroline S. Fox
Joseph F. Polak
Philip A. Wolf
Ralph A. D’Agostino, Sr.
Christopher J. O’Donnell
Source :
Journal of Lipid Research, Vol 45, Iss 10, Pp 1868-1875 (2004)
Publication Year :
2004
Publisher :
Elsevier, 2004.

Abstract

The aim of this study was to determine the association between APOE genotype and carotid atherosclerosis, defined as intimal-medial thickness (IMT) and stenosis, and to assess if other cardiovascular risk factors modify this association. A total of 1,315 men and 1,408 women from the Framingham Offspring Study underwent carotid ultrasound during examination cycle 6 and had complete data on APOE genotype. Three APOE genotype groups were defined: APOE2 (including E2/E2, E3/E2 genotypes), APOE3 (E3/E3), and APOE4 (including E4/E3, E4/E4 genotypes). Carotid IMT and the presence of carotid stenosis > 25% were determined by ultrasonography. In women, the APOE2 group was associated with lower carotid IMT (0.67 vs. 0.73 mm) and lower prevalence of stenosis (odds ratio = 0.49; 95% confidence interval = 0.30–0.81) compared with the APOE3 group. In men, APOE genotype was not associated with carotid IMT or stenosis in the whole group; however, diabetes modified the association between APOE genotype and carotid IMT (P for interaction = 0.044). Among men with diabetes, the APOE4 group was associated with a higher internal carotid artery IMT (1.22 mm) than the APOE3 group (0.90 mm) or the APOE2 group (0.84 mm).The E2 allele was associated with lower carotid atherosclerosis in women, and the E4 allele was associated with higher internal carotid IMT in diabetic men.

Details

Language :
English
ISSN :
00222275
Volume :
45
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Journal of Lipid Research
Publication Type :
Academic Journal
Accession number :
edsdoj.7a98ff5d204b4942874631ecff9fff68
Document Type :
article
Full Text :
https://doi.org/10.1194/jlr.M400114-JLR200