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Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights

Authors :
Kushagra Nagori
Kartik T. Nakhate
Krishna Yadav
Ajazuddin
Madhulika Pradhan
Source :
Future Pharmacology, Vol 3, Iss 4, Pp 877-907 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Alzheimer’s disease (AD) is a progressive, multifactorial, and unremitting neurodegenerative disease characterized by memory loss, personality changes, and cognitive impairment. It has become more prevalent in recent years. Therefore, understanding the pathophysiology of AD and developing efficient therapeutic strategies are essential. Moreover, the progression of the disease is unaffected by the pharmaceutical approaches discovered to date. Additionally, the failure of over 200 potential drug candidates in clinical trials over the past decade suggests the complexity and difficulty of both the disease and its underlying causes. Therefore, research focused on medicinal plant-based natural products in the search for novel neuroprotective therapeutic candidates for AD is essential. Indeed, several scientific investigations have demonstrated the efficacy of many medicinal plants and their principal phytochemicals in the treatment of AD. This review article covered the pathophysiological mechanisms of AD, the necessity for natural products as anti-AD treatments, and the most recent preclinical studies revealing the function of neuroprotective medicinal plants and their bioactive compounds in the effective management of AD. In addition, the review also presents clinical trial data of promising anti-AD formulations/agents of plant origin. Revealing recent findings and highlighting the clinical trial data related to the development of new treatments for AD would promote further research in this field and pave the way for the development of more effective and safe treatments for this debilitating disease.

Details

Language :
English
ISSN :
26739879
Volume :
3
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Future Pharmacology
Publication Type :
Academic Journal
Accession number :
edsdoj.7aaa2d6379364804aabeab3929c7a127
Document Type :
article
Full Text :
https://doi.org/10.3390/futurepharmacol3040053