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Circulating dipeptidyl peptidase 3 and bio-adrenomedullin levels are associated with impaired outcomes in critically ill COVID-19 patients: a prospective international multicentre study
- Source :
- ERJ Open Research, Vol 9, Iss 1 (2023)
- Publication Year :
- 2023
- Publisher :
- European Respiratory Society, 2023.
-
Abstract
- Introduction Dipeptidyl peptidase-3 (DPP3) is a protease involved in the degradation of several cardiovascular mediators. Adrenomedullin (bio-ADM) is a peptide essential for regulation of endothelial barrier function. In different shock-pathologies, both biomarkers are associated with disease severity, organ dysfunction and mortality. Associations with outcome in critically ill COVID-19 patients are unknown. The objectives of the present study were to investigate associations of bio-ADM and “circulating DPP3” (cDPP3) with short-term outcome in critically ill COVID-19 patients (n=80). Methods A multicentre prospective cohort study was performed. The primary end-point was 28-day mortality. Secondary end-points included different severities of acute kidney injury (AKI). Results cDPP3 levels were mainly associated with 28-day mortality; Area under the receiver operating characteristics (AUROCs) of 0.69 (0.56–0.82, p=0.023), 0.77 (0.64–0.90, p
- Subjects :
- Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 23120541
- Volume :
- 9
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- ERJ Open Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.7ab5f4dc01a4483ba7a4db431332a82e
- Document Type :
- article
- Full Text :
- https://doi.org/10.1183/23120541.00342-2022